Characterizing the lncRNA Landscape of Ovarian Cancer

Very little is known about the role of long noncoding RNAs (lncRNAs) in epithelial ovarian cancer (EOC) development. Research in the Lawrenson Laboratory uses RNA-sequencing technologies to catalogue the lncRNA transcriptome of ovarian cancers and their precursor tissues: specifically ovarScreen Shot 2016-04-08 at 3.53.00 PMian surface epithelial cells and fallopian tube secretory cells for the most common subtype (high-grade serous). A current focus of the Lawrenson Lab is a specific lncRNA — UCA1 — that is associated with poor outcomes in EOC and we are using state-of-the-art antisense purification techniques to unravel the mechanistic role of this lncRNA in EOC cell biology.